Screening Assessment for the Challenge Propane, 2-nitro- (2-Nitropropane)
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ENZYMATIC DENITRIFI~ATION OF 2-NITROPROPANE IN UNINDUCED MOUSE LIVER MICROSOMES (Strain differences; microsomal metabolism; 2nitropropane)
Hepatic microsomes from 5 strains of untreated mice were tested for the ability to en~ymatically cleave the nitro group from 2nitropropane (2NP). All strains showed significant NADPH-dependent nitrite release at pH 7.6 and pH 8.8. Statistical differences in nitrite-releasing activity between strains were found between BALB and PL/J and ATH strains at pH 7.6. At pH 8.8, BI0.M differed from CD-l ...
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The pharmaceutical industry is moving through a period of great change. Not only are the global players consolidating, but companies are fundamentally changing the way they approach the market. “Big Pharma” has learned to focus on what it does best that is, the discovery and marketing of new products. All other endeavours are increasingly being out-sourced to a growing number of support laborat...
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These experiments investigate the decomposition mechanisms of geminal dinitro energetic materials by photolytically generating two key intermediates: 2-nitropropene and 2-nitro-2-propyl radicals. To characterize the unimolecular dissociation of each intermediate, we form them under collision-free conditions using the photodissociation of 2-bromo-2-nitropropane; the intermediates are formed at h...
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Microorganisms that biosynthesize broad-specificity oxygenases to initiate metabolism of linear and branched-chain alkanes, nitroalkanes, cyclic ketones, alkenoic acids, and chromenes were surveyed for the ability to biodegrade trichloroethylene (TCE). The results indicated that TCE oxidation is not a common property of broad-specificity microbial oxygenases. Bacteria that contained nitropropan...
متن کاملCrystal structure of bis(bis{μ3-3-methyl-3-[(4-nitro-2-oxidobenzylidene)amino]propane-1,3-diolato}tris[chlorido(dimethyl sulfoxide)iron(III)]) dimethyl sulfoxide heptasolvate dihydrate
The title compound, [Fe3(C11H11N2O5)2Cl3(C2H6OS)3]2·7C2H6OS·2H2O, was isolated accidentally from an Fe0-NiCl2·6H2O-H3L-TEA-DMSO system [where H3L is the product of the condensation between p-nitro-salicyl-aldehyde and 2-amino-2-methyl-propane-1,3-diol and dimethyl sulfoxide (DMSO), and TEA is triethylamine]. The structure is based on a trinuclear {Fe3(μ-O)4} core, with an angular arrangement of...
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تاریخ انتشار 2010